Get up and move

Fifteen years of research at the Mayo Clinic has shown that sitting all day long at the office is actually quite harmful to human health and that people who are obese tend to be seated two hours more than leaner people.
Inactivity (4 hours or more) causes a near shut- down of an enzyme that controls fat and cholesterol metabolism. To keep this enzyme active and increase your fat-burning, break up long periods of downtime by standing up—for example, while talking on the phone.